Vitamin D is now believed to have a significant role in cardiac signal transduction and regulation of gene expression, and thus influences normal cardiomyocyte function.It has been reported to provide cardioprotection through its anti-inflammatory, anti-apoptotic and anti-fibrotic actions; and to prevent cardiac remodeling, Ca2+-handling defects, and abnormal electrophysiological patterns.A vitamin D deficient state has been associated in the pathogenesis of heart failure; VITAMIN C COMPLEX however, while many clinical studies report a benefit of vitamin D to heart function, other clinical studies are inconsistent with these findings.
These uncertainties have led to a discord in the recommendation of vitamin D supplementation for the treatment of heart failure or as a preventive agent in patients deemed to be at risk for cardiac dysfunction.Accordingly, this article is intended to describe some of the mechanisms/sites of action of vitamin D in different animal models of heart failure, as well as to review the clinical observations and challenges in the interpretation and understanding of the clinical relevance of vitamin D in relation Samsung RB29FWRNDBC A+ 600mm No Frost Fridge Freezer with 290L Capacity in Black to heart function.